If you're looking to discover somewhere new, look no further than Defiance. Whether you're planning to stay for a night or for the week, the area around Defiance has accommodation options to fit every need. Search for hotels in Defiance with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Defiance hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Defiance hotel deals are here with our lowest price guarantee.
Hotels & Accommodation in Defiance
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Where to stay in Defiance?
Drury Inn & Suites St. Louis St. Peters
Drury Inn & Suites St. Louis St. Peters
9.2 out of 10, Wonderful, (1002)
The price is R1 910
R2 195 total
includes taxes & fees
17 Aug - 18 Aug
Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
8.8 out of 10, Excellent, (1007)
The price is R1 589
R1 874 total
includes taxes & fees
27 Jul - 28 Jul
The Wildwood Hotel
The Wildwood Hotel
9.2 out of 10, Wonderful, (1551)
The price is R1 478
R1 792 total
includes taxes & fees
22 Jul - 23 Jul
Drury Inn & Suites Southwest St. Louis
Drury Inn & Suites Southwest St. Louis
9.4 out of 10, Exceptional, (1000)
The price is R2 051
R2 399 total
includes taxes & fees
10 Aug - 11 Aug
LAKEVIEWINN
LAKEVIEWINN
5.0 out of 10, (16)
The price is R1 364
R1 541 total
includes taxes & fees
26 Jul - 27 Jul
Super 8 by Wyndham Washington
Super 8 by Wyndham Washington
8.4 out of 10, Very good, (658)
The price is R1 609
R1 832 total
includes taxes & fees
24 Jul - 25 Jul
Comfort Inn & Suites St. Louis - O'Fallon
Comfort Inn & Suites St. Louis - O'Fallon
7.6 out of 10, Good, (1000)
The price is R1 605
R1 893 total
includes taxes & fees
20 Jul - 21 Jul
Best Western Plus Washington Hotel
Best Western Plus Washington Hotel
9.0 out of 10, Wonderful, (577)
The price is R2 300
R2 619 total
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
9.2 out of 10, Wonderful, (910)
The price is R2 015
R2 345 total
includes taxes & fees
27 Jul - 28 Jul
Quality Inn
Quality Inn
8.2 out of 10, Very good, (810)
The price is R1 667
R1 883 total
includes taxes & fees
18 Aug - 19 Aug
Hampton Inn St. Louis/Chesterfield
Hampton Inn St. Louis/Chesterfield
8.6 out of 10, Excellent, (1001)
The price is R1 773
R2 057 total
includes taxes & fees
08 Aug - 09 Aug
Holiday Inn Express & Suites St Peters by IHG
Holiday Inn Express & Suites St Peters by IHG
9.2 out of 10, Wonderful, (324)
The price is R1 516
R1 847 total
includes taxes & fees
10 Aug - 11 Aug
Courtyard by Marriott St. Louis Chesterfield
Courtyard by Marriott St. Louis Chesterfield
9.0 out of 10, Wonderful, (538)
The price is R1 804
R2 099 total
includes taxes & fees
27 Jul - 28 Jul
Hampton Inn & Suites St. Louis/Chesterfield
Hampton Inn & Suites St. Louis/Chesterfield
8.6 out of 10, Excellent, (794)
The price is R1 804
R2 099 total
includes taxes & fees
27 Jul - 28 Jul
Hilton Garden Inn St. Louis/O'Fallon MO
Hilton Garden Inn St. Louis/O'Fallon MO
8.8 out of 10, Excellent, (690)
The price is R2 552
R3 026 total
includes taxes & fees
01 Aug - 02 Aug
Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHG
8.6 out of 10, Excellent, (735)
The price is R1 997
R2 356 total
includes taxes & fees
27 Jul - 28 Jul
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
8.4 out of 10, Very good, (1014)
The price is R1 591
R1 837 total
includes taxes & fees
29 Jul - 30 Jul
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
8.4 out of 10, Very good, (1005)
The price is R1 683
R1 943 total
includes taxes & fees
03 Aug - 04 Aug
River Sirens Hotel
River Sirens Hotel
9.8 out of 10, Exceptional, (159)
The price is R2 378
R2 707 total
includes taxes & fees
20 Jul - 21 Jul
Super 8 by Wyndham Eureka/Six Flags Nearby
Super 8 by Wyndham Eureka/Six Flags Nearby
7.0 out of 10, Good, (1002)
The price is R1 183
R1 377 total
includes taxes & fees
10 Aug - 11 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Defiance
Family friendly
Top landmarks in Defiance
August A. Busch Memorial Conservation Area
If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area? a park located 30.2 mi (48.6 km) from the centre of St. Louis.
Learn more about Defiance
Defiance is well known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.
Check out reviews of Defiance hotels guests love
The Wildwood Hotel
10/10 Excellent
Frequently asked questions
Find out more about Defiance
Find out more about Defiance
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- Crowne Plaza St. Louis Airport by IHG
- Drury Plaza Hotel St. Louis St. Charles
- Hampton Inn St. Charles St. Peters
- Drury Plaza Hotel St. Louis Chesterfield
- Comfort Inn St. Louis - Westport Event Center
- Drury Plaza Hotel St. Louis Creve Coeur
- Comfort Suites St Charles - St Louis
- Motel 6 Maryland Heights, MO
- Holiday Inn St. Louis - Creve Coeur by IHG
- Country Inn & Suites by Radisson, St. Charles Historic District
- Comfort Inn & Suites St. Louis - O'Fallon
- Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
- Holiday Inn Express St. Louis West - O'Fallon by IHG
- Red Roof Inn St Louis - Westport/ Maryland Heights
- DoubleTree by Hilton St. Louis - Westport
- Best Western Plus Fenton
- Extended Stay America Suites St Louis St Peters
- Extended Stay America Select Suites St Louis Earth City
- Hampton Inn St. Louis/Chesterfield
- Hilton Garden Inn Chesterfield
- Sleep Inn & Suites O'Fallon MO - Technology Drive
- The Lodge Hotel and Banquets
- Comfort Inn St. Louis Airport
- Holiday Inn St. Louis West Six Flags by IHG
- Embassy Suites by Hilton St. Louis Airport
- Tru by Hilton St. Charles St. Louis, MO
- Holiday Inn Express & Suites St Peters by IHG
- Comfort Inn & Suites St. Louis - Chesterfield
- Quality Inn
- Courtyard St. Louis Airport/Earth City
- Fairfield Inn & Suites by Marriott St. Louis Chesterfield
- Super 8 by Wyndham St Charles
- Days Inn by Wyndham St Peters/St Charles
- Hampton Inn St. Louis/Westport
- Homewood Suites by Hilton St. Louis-Chesterfield
- Embassy Suites by Hilton St. Louis St. Charles
- Sonesta Simply Suites St Louis Earth City
- Staybridge Suites O'Fallon Chesterfield by IHG
- LAKEVIEWINN
- Holiday Inn St. Louis Arpt West-Earth City by IHG
- Hampton Inn & Suites St. Charles Old Town Area
- Extended Stay America Select Suites - St. Louis - Westport - E Lackland Rd
- Holiday Inn Express & Suites St. Louis West - Fenton by IHG
- Sleep Inn & Suites
- Holiday Inn Express & Suites Wentzville St Louis West by IHG
- DoubleTree by Hilton Hotel St. Louis - Chesterfield
- Marriott St. Louis West
- SpringHill Suites by Marriott St. Louis Airport/Earth City
- Economy Inn Wentzville
- Baymont by Wyndham Warrenton