Hotels & Accommodation in Cayo Guillermo

your current months are January, 2025 and February, 2025.
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February 2025
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Where to stay in Cayo Guillermo?

Top landmarks in Cayo Guillermo

Cayo Guillermo Beach

Cayo Guillermo Beach

Why not spend a care-free afternoon at Cayo Guillermo Beach during your travels in Cayo Guillermo? While you're in the area, wander around the natural setting.

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Cayo Guillermo Beach

Cayo Guillermo Marina

Cayo Guillermo Marina is just one of the places to see in Cayo Guillermo, so why not enjoy the other things to explore during your travels? While you're in the area, stroll along the white-sand beaches.

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Cayo Guillermo Marina

Learn more about Cayo Guillermo

The region around Cayo Guillermo is home to attractions such as Cayo Guillermo Beach and Cayo Guillermo Marina.

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Frequently asked questions

Can I book a refundable accommodation option in Cayo Guillermo?
If you want the flexibility to change your plans to Cayo Guillermo, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Cayo Guillermo be like during my visit?
With an average temperature of 24°C during the coldest months, Cayo Guillermo is a great place to visit at any time of year.
Why should I book my Cayo Guillermo hotel with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.