Hotels & Accommodation in Seneca

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This weekend
30 Oct - 01 Nov
Next weekend
06 Nov - 08 Nov

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on .

A poolside area with outdoor seating and a view of a lake and forested hills.

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.2 out of 10, Wonderful, (289 reviews)
Minutes from Clemson University and Lakes Keowee and Hartwell, this Seneca hotel offers free breakfast and parking. Refresh at the outdoor pool or fitness centre after exploring nearby Golden Corner Plaza and Gignilliat Community Centre.
The price is R1 993
R2 193 total
includes taxes & fees
08 Nov - 09 Nov
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel dining area with a long table, multiple chairs, and a bar in the background.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (764 reviews)
Just 5 minutes from Lake Keowee, this hotel offers a 24-hour fitness centre and seasonal outdoor swimming. Enjoy complimentary breakfast, WiFi, and parking while staying close to Clemson University. Guests consistently praise the helpful staff and clean accommodation.
The price is R2 064
R2 270 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn & Suites Seneca-Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (901 reviews)
This convenient Seneca hotel offers a complimentary morning meal, fitness centre, and free parking just 5 minutes from campus. Guests praise the attentive staff, while Littlejohn Coliseum and Sloan Tennis Centre are located nearby.
The price is R1 690
R1 858 total
includes taxes & fees
19 Nov - 20 Nov
Tru by Hilton Seneca Clemson
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (697 reviews)
Located within a 10-minute drive of Clemson University, this Seneca hotel offers a seasonal outdoor pool and free daily breakfast. Guests appreciate the helpful staff and clean rooms, while enjoying convenient access to local attractions.
The price is R1 610
R1 771 total
includes taxes & fees
30 Nov - 01 Dec
Best Western Seneca-Clemson
A hotel room with a bed, a desk with a computer, a TV, a mirror, and a bathroom visible in the background.

5. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (766 reviews)
Serene hotel within a 15-minute drive of Clemson University offers a seasonal outdoor pool, complimentary WiFi, parking, and breakfast. Toy Train Park and The Gauntlet attractions are nearby, with guests consistently praising the quiet atmosphere and attentive service.
The price is R1 406
R1 651 total
includes taxes & fees
06 Nov - 07 Nov
Quality Inn Seneca US-123
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

6. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1 000 reviews)
Unwind at this lakeside retreat with a poolside bar and seasonal outdoor pool just minutes from Clemson University. The 24-hour fitness centre and hot tub provide recreation options while the restaurant and lounge offer on-site dining convenience.
The price is R1 811
R2 248 total
includes taxes & fees
08 Nov - 09 Nov
Lakeside Lodge Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, Good, (792 reviews)
This Seneca motel offers easy access to Clemson University and Lake Keowee. Take a refreshing dip in the seasonal outdoor pool after exploring nearby Lake Hartwell. Free WiFi, parking, and daily on-the-go breakfast add exceptional value.
The price is R1 257
R1 383 total
includes taxes & fees
30 Nov - 01 Dec
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (116 reviews)
Tucked between Lake Hartwell and Lake Keowee, these charming cabins offer serene patios and well-equipped kitchenettes. Just minutes from outdoor recreation areas and Cross Creek Plantation Golf, with free parking and cosy climate control for year-round comfort.
The price is R1 396
R2 266 total
includes taxes & fees
30 Nov - 01 Dec
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

9. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (903 reviews)
Moments from Lake Hartwell, this hotel blends walkable access to campus with comfort. Enjoy attentive service, a welcoming restaurant, and stylish bar where you can unwind. Just a 13-minute walk from Clemson Station connects you to broader adventures.
The price is R3 473
R3 855 total
includes taxes & fees
08 Nov - 09 Nov
The Shepherd Hotel Downtown Clemson
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

10. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
Clemson
9.4 out of 10, Exceptional, (1 005 reviews)
Set on the grounds of Clemson University, this welcoming hotel offers direct access to Walker Golf Course, a seasonal outdoor pool, and poolside bar. Enjoy American cuisine at Sole on the Green or squeeze in a workout at the 24-hour fitness centre while exploring campus.
The price is R2 310
R2 564 total
includes taxes & fees
30 Nov - 01 Dec
Clemson University's James F. Martin Inn
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

11. The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (657 reviews)
Experience Southern hospitality at this refined Clemson hotel just minutes from campus attractions. Unwind with a cocktail at the stylish bar after exploring nearby Sloan Tennis Centre and Littlejohn Coliseum. Free parking and convenient location make this an ideal collegiate getaway.
The price is R2 527
R2 805 total
includes taxes & fees
24 Nov - 25 Nov
The Abernathy of Clemson
A modern kitchen area with a bar counter and seating.

12. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
2.5 star property
Clemson
8.8 out of 10, Excellent, (652 reviews)
Unwind at this well-positioned hotel near Larry W. Abernathy Waterfront Park, offering a seasonal outdoor pool for morning swims. Free breakfast, WiFi, and parking await, with Clemson Station just a 19-minute walk away.
The price is R1 822
R2 022 total
includes taxes & fees
07 Nov - 08 Nov
Hampton Inn Clemson-University Area
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.

13. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
2.5 star property
Clemson
8.8 out of 10, Excellent, (998 reviews)
Minutes from Clemson University and Lake Hartwell, this hotel offers complimentary WiFi, parking, and breakfast. Work out in the fitness centre before exploring nearby attractions like the African American Museum and waterfront park.
The price is R2 143
R2 379 total
includes taxes & fees
08 Nov - 09 Nov
Holiday Inn Express & Suites Clemson by IHG
A modern kitchen with a microwave, coffee maker, and bar stools.

14. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.4 out of 10, Very good, (1 002 reviews)
Take a dip in the seasonal outdoor pool at this Clemson hotel, just a 15-minute drive from Clemson University. Enjoy free breakfast, parking, and fitness centre access, with African American Museum and Waterfront Park nearby.
The price is R1 681
R1 866 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Clemson - University Area
A bar area with a granite countertop, bar stools, and a menu board.

15. Courtyard Marriott Clemson

Courtyard Marriott Clemson
3.0 star property
Clemson
9.0 out of 10, Wonderful, (591 reviews)
This business-friendly spot near Clemson Area African American Museum features American cuisine at The Bistro, plus a fitness centre and bar. Enjoy free WiFi and parking while staying close to South Carolina Botanical Gardens.
The price is R1 715
R1 903 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard Marriott Clemson
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

16. The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (935 reviews)
Enjoy free WiFi and parking at this hotel just 5 minutes from Clemson University. Clean rooms provide a comfortable base while exploring nearby Botanical Gardens and African American Museum. The friendly staff ensures a pleasant stay in Clemson.
The price is R2 476
R2 748 total
includes taxes & fees
08 Nov - 09 Nov
The Inn at Patrick Square
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

17. Inn @ Clemson

Inn @ Clemson
2.5 star property
Clemson
8.0 out of 10, Very good, (1 010 reviews)
Take advantage of the complimentary breakfast, WiFi and parking at this hotel near Lake Hartwell and Clemson University. Guests praise the helpful staff, clean rooms and quiet environment. The fitness centre adds value for active travellers.
The price is R1 479
R1 641 total
includes taxes & fees
05 Nov - 06 Nov
Inn @ Clemson
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

18. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.0 out of 10, Very good, (1 003 reviews)
Walking distance from Clemson Station, this welcoming hotel sits just 5 minutes from the university campus. After a free breakfast, cool off in the seasonal outdoor pool or hit the 24-hour fitness centre. Nearby attractions and quiet, comfortable rooms await.
The price is R1 681
R1 866 total
includes taxes & fees
30 Nov - 01 Dec
Best Western Plus Clemson Hotel & Conference Center
A kitchen with a coffee maker, microwave, and refrigerator.

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
2.0 star property
Walhalla
7.6 out of 10, Good, (199 reviews)
Wake up to complimentary continental breakfast at this welcoming Walhalla motel. Located near Art Circle Gallery and Goldfish Pond, the property offers free WiFi and parking. Just a 22-minute drive from Clemson Station for easy regional exploration.
The price is R1 328
R1 480 total
includes taxes & fees
29 Nov - 30 Nov
Rodeway Inn & Suites Walhalla
A spacious living room with a fireplace, large windows, and a flat-screen TV mounted above the mantel.

20. Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
Anderson
9.0 out of 10, Wonderful, (795 reviews)
This Anderson hotel offers quiet comfort with Garden Grille breakfast and a welcoming bar. After exploring nearby attractions, return to clean rooms with refrigerators and microwaves. Guests praise the helpful staff and free parking.
The price is R1 822
R2 022 total
includes taxes & fees
08 Nov - 09 Nov
Hilton Garden Inn Anderson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Get last-minute hotel deals in Seneca and save more

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Showing deals for:30 Oct - 31 Oct
A hotel room with a bed, a desk with a computer, a TV, a mirror, and a bathroom visible in the background.
Quality Inn Seneca US-123

Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (766 reviews)
The price is R1 562
per night
R1 827 total
includes taxes & fees
Quality Inn Seneca US-123
Showing deals for:31 Oct - 01 Nov
A hotel room with a bed, a desk with a computer, a TV, a mirror, and a bathroom visible in the background.
Quality Inn Seneca US-123

Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (766 reviews)
The price is R1 562
per night
R1 827 total
includes taxes & fees
Quality Inn Seneca US-123
Showing deals for:06 Nov - 08 Nov
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (697 reviews)
The price is R1 751
per night
R3 853 total
includes taxes & fees
Best Western Seneca-Clemson

Check out pet-friendly hotels in Seneca

An outdoor patio area with a fire pit, seating, and string lights.
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (901)
The price is R1 690
R1 858 total
includes taxes & fees
19 Nov - 20 Nov
Tru by Hilton Seneca Clemson
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You can also stay at hotels with a pool in Seneca

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1000)
The price is R1 811
R2 248 total
includes taxes & fees
08 Nov - 09 Nov
Lakeside Lodge Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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When is the best time to visit Seneca?

Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in October
Currently viewing crowd sizes and weather for October.
Typical weather for Seneca
October
High 23°C / low 12°C. Sunny most days.
View properties in October
23°
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October, no crowd data, average high temperature 23 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
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17°
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November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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12°
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December, no crowd data, average high temperature 12 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
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10°
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January, no crowd data, average high temperature 10 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
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13°
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February, no crowd data, average high temperature 13 degrees Celsius, average low temperature 3 degrees Celsius. Partly sunny.
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17°
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March, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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22°
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April, no crowd data, average high temperature 22 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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26°
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May, no crowd data, average high temperature 26 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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31°
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June, no crowd data, average high temperature 31 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
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32°
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July, no crowd data, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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31°
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August, no crowd data, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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28°
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September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
Monthly weather averages (˚C)

Top neighbourhoods in Seneca

A lakeside scene with autumn foliage, a clear sky, and a sunset.

Downtown

Seneca's Downtown neighbourhood has lots of places to visit, such as Oconee County Library Seneca Branch and Blue Ridge Arts Center.

A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

Seneca's Serenity Bay neighbourhood offers attractions, including Lake Keowee.

A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

Seneca's Pine Ridge Point neighbourhood offers attractions, including Lake Keowee.

Indian Oaks

Seneca's Indian Oaks neighbourhood offers attractions, including Lake Keowee.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

See all hotels in Seneca
A sunset over a lake surrounded by dense forests and residential areas.

Check out reviews of Seneca hotels guests love

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

10/10 Excellent
"Very clean room, recently renovated. Comfy bed!"
Rhiannon 1-night trip
Posted 1 day ago
Days Inn by Wyndham Seneca / Clemson Area

Frequently asked questions

Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 217 holiday homes. In addition, there are 24 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.