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Where to stay in Seneca?
Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on 18 September 2026.
1. Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson AreaSeneca
R1 973
R2 170 total
includes taxes & fees
27 Sept - 28 Sept
2. Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
R1 734
R1 908 total
includes taxes & fees
18 Oct - 19 Oct
3. Best Western Seneca-Clemson
Best Western Seneca-ClemsonSeneca
R1 577
R1 734 total
includes taxes & fees
21 Sept - 22 Sept
4. Quality Inn Seneca US-123
Quality Inn Seneca US-123Seneca
R1 230
R1 451 total
includes taxes & fees
27 Sept - 28 Sept
5. Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson AreaSeneca
R1 278
R1 406 total
includes taxes & fees
20 Sept - 21 Sept
6. Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
R1 773
R2 201 total
includes taxes & fees
21 Sept - 22 Sept
7. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
R1 513
R2 380 total
includes taxes & fees
19 Oct - 20 Oct
8. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Beautiful Lake Keowee Home w/ Boat Dock & Fire PitSeneca
R6 329
R12 764 total
includes taxes & fees
27 Sept - 28 Sept
9. Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
R2 061
R2 287 total
includes taxes & fees
20 Sept - 21 Sept
10. The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown ClemsonClemson
R3 889
R4 316 total
includes taxes & fees
27 Sept - 28 Sept
11. Hampton Inn Clemson-University Area
Hampton Inn Clemson-University AreaClemson
R1 721
R1 910 total
includes taxes & fees
27 Sept - 28 Sept
12. The Abernathy of Clemson
The Abernathy of ClemsonClemson
R2 621
R2 909 total
includes taxes & fees
11 Oct - 12 Oct
13. Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
R1 755
R1 948 total
includes taxes & fees
24 Sept - 25 Sept
14. Holiday Inn Express & Suites Clemson by IHG
Holiday Inn Express & Suites Clemson by IHGClemson
R2 099
R2 330 total
includes taxes & fees
20 Sept - 21 Sept
15. Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference CenterClemson
R1 784
R1 980 total
includes taxes & fees
21 Sept - 22 Sept
16. The Inn at Patrick Square
The Inn at Patrick SquareClemson
R2 424
R2 691 total
includes taxes & fees
27 Sept - 28 Sept
17. Courtyard Marriott Clemson
Courtyard Marriott ClemsonClemson
R2 182
R2 422 total
includes taxes & fees
27 Sept - 28 Sept
18. Inn @ Clemson
Inn @ ClemsonClemson
R1 611
R1 788 total
includes taxes & fees
20 Sept - 21 Sept
19. Rodeway Inn & Suites Walhalla
Rodeway Inn & Suites WalhallaWalhalla
R1 318
R1 469 total
includes taxes & fees
27 Sept - 28 Sept
20. Country Inn & Suites by Radisson, Anderson, SC
Country Inn & Suites by Radisson, Anderson, SCAnderson
R1 577
R1 750 total
includes taxes & fees
11 Oct - 12 Oct
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R1 318
per night
R3 100 total
includes taxes & fees
R2 081
per night
R4 577 total
includes taxes & fees
R1 853
per night
R4 077 total
includes taxes & fees
R2 107
per night
R4 636 total
includes taxes & fees
R1 936
per night
R4 777 total
includes taxes & fees
R1 570
per night
R3 454 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
R3 238
per night
R8 555 total
includes taxes & fees
R3 042
per night
R9 978 total
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape
6 Mi to South Cove Boat Ramp! Lake Keowee EscapeSeneca
R3 498
per night
R11 461 total
includes taxes & fees
Condo on Lake Hartwell 3 Mi to Clemson Stadium
Condo on Lake Hartwell 3 Mi to Clemson StadiumSeneca
R3 791
per night
R12 171 total
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay
Screened Patio & Yard: Clemson Weekends/lakes StaySeneca
R3 937
per night
R13 588 total
includes taxes & fees
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Home w/ Lake Keowee Access: Sleeps 7, Coffee BarSeneca
R2 945
per night
R10 310 total
includes taxes & fees
Clemson Weekends 3 Mi From Memorial Stadium
Clemson Weekends 3 Mi From Memorial StadiumSeneca
R4 344
per night
R14 483 total
includes taxes & fees
Lakefront Fun Near Clemson! Retreat w/ Pool Access
Lakefront Fun Near Clemson! Retreat w/ Pool AccessSeneca
R6 215
per night
R17 066 total
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails
Lake Keowee Gem! Close to Clemson & Hiking TrailsSeneca
R8 257
per night
R22 435 total
includes taxes & fees
Check out pet-friendly hotels in Seneca
R1 230
R1 451 total
includes taxes & fees
27 Sept - 28 Sept
R1 734
R1 908 total
includes taxes & fees
18 Oct - 19 Oct
R1 278
R1 406 total
includes taxes & fees
20 Sept - 21 Sept
R1 773
R2 201 total
includes taxes & fees
21 Sept - 22 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
R1 513
R2 380 total
includes taxes & fees
19 Oct - 20 Oct
You may also like hotels with pools in Seneca
R1 577
R1 734 total
includes taxes & fees
21 Sept - 22 Sept
R1 773
R2 201 total
includes taxes & fees
21 Sept - 22 Sept
R1 230
R1 451 total
includes taxes & fees
27 Sept - 28 Sept
R1 973
R2 170 total
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
R1 278
R1 406 total
includes taxes & fees
20 Sept - 21 Sept
Go beyond your typical stay in Seneca
Pet friendly
Pool
Hot tub
Cabin
Apartment
Family friendly
Cottage
Condo
Our prices for hotels in Seneca are cheapest in December
Our prices for hotels in Seneca are cheapest in December
Top neighbourhoods in Seneca
Downtown
Seneca's Downtown neighbourhood has lots of places to visit, such as Oconee County Library Seneca Branch and Blue Ridge Arts Center.
Serenity Bay
Seneca's Serenity Bay neighbourhood offers attractions, including Lake Keowee.
Pine Ridge Point
Seneca's Pine Ridge Point neighbourhood offers attractions, including Lake Keowee.
Indian Oaks
Seneca's Indian Oaks neighbourhood offers attractions, including Lake Keowee.
Top landmarks in Seneca
High Falls County Park
High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
Blue Ridge Field
Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
Oconee County Library Seneca Branch
Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
South Cove Park
South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
Friendship Recreation Area
Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
Wyndham Plaza
If you like shopping, take time out to go to Wyndham Plaza when in Seneca.
World of Energy
If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.
The Gauntlet
If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
Learn more about Seneca
Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.
See all hotels in Seneca
Frequently Asked Questions
Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 219 holiday homes. In addition, there are 23 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.
Find out more about Seneca
Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on 18 September 2026.