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Hotels & Accommodation in Panacea

October 2026
10
November 2026

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Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Where to stay in Panacea?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Panacea on Hotels.com. These Panacea hotels consistently deliver on quality, location and traveller experience. Last updated on 10 October 2026.
A pink door with a window, set in a corrugated metal exterior with wooden trim.
A kitchen with a wooden countertop, a built-in sink, and a trash can.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.
A wooden bench in a natural setting with trees and a body of water in the background.

1. The Panacea Motel

The Panacea Motel
Panacea
R1 966
R2 193 total
includes taxes & fees
11 Oct - 12 Oct
The Panacea Motel
A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.
A hotel lobby with a coffee bar, seating area, and a clock on the wall.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A modern hotel lobby with a sofa, armchairs, a desk, and a TV.

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
R1 915
R2 135 total
includes taxes & fees
25 Oct - 26 Oct
Best Western Wakulla Inn & Suites
A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.
A hotel room with a bed, a desk, a chair, a small table with a vase, a trash bin, and a wooden door.
Fitness facility
A hotel with a red facade, a covered entrance, and palm trees.

3. Wildwood Inn

Wildwood Inn
Crawfordville
R1 903
R2 187 total
includes taxes & fees
05 Nov - 06 Nov
Wildwood Inn
A spacious lobby with leather sofas, a coffee table, and a large window with arched frames.
A spacious lobby with high ceilings, ornate ceiling decorations, and large windows.
A spacious dining area with multiple tables and chairs, large windows, and hanging chandeliers.
A boat docked at a pier with passengers on board.

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
R1 866
R2 081 total
includes taxes & fees
09 Nov - 10 Nov
The Lodge at Wakulla Springs
A bar area with a long counter, stools, and a variety of bottles and glasses.
A resort with multiple tennis courts, a swimming pool, and a golf course.
A living room with a sofa set, a television, and a ceiling fan.
A swimming pool with lounge chairs, palm trees, and a clear blue sky.

5. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
R2 075
R2 917 total
includes taxes & fees
11 Oct - 12 Oct
St James Bay Golf & Pickleball Resort
A marina with boats docked, a small building, and a clear sky.
A marina with multiple docks and boats, connected by walkways, and surrounded by greenery and buildings.
A pool area with a table and chairs, a building with doors, and a palm tree.
A spacious room with a pool table, a billiards table, and a dining area with chairs and a table.

6. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
R2 979
R3 292 total
includes taxes & fees
12 Oct - 13 Oct
The Moorings Hotel and Marina
A covered patio with a table and chairs, a wooden ceiling fan, and a view of the surrounding greenery.
A hotel with a white facade, red accents, and a sign indicating it is the Old Carrabelle Hotel.
A yellow door with a window, a potted plant, a white wall-mounted light fixture, and a staircase with yellow curtains.
A cozy living room with a sofa, a small table, and a ceiling fan.

7. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
R1 657
R1 831 total
includes taxes & fees
11 Oct - 12 Oct
The Old Carrabelle Hotel
A hotel room with two beds, a nightstand, a lamp, and a bathroom visible through an open door.
A motel with a single-story structure, a covered parking area, and a palm tree in front.
A bathroom with a toilet, shower, and sink with a marble countertop.
A motel with a row of rooms, a staircase, and a parking area.

8. Franklin Inn

Franklin Inn
Carrabelle
R1 725
R1 906 total
includes taxes & fees
13 Oct - 14 Oct
Franklin Inn
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A pink door with a window, set in a corrugated metal exterior with wooden trim.
A kitchen with a wooden countertop, a built-in sink, and a trash can.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a sink. There are wooden shelves above the counter and a window with a view.
A wooden bench in a natural setting with trees and a body of water in the background.

The Panacea Motel

The Panacea Motel
Panacea
R2 278
per night
R5 079 total
includes taxes & fees
The Panacea Motel
A modern kitchen with white cabinets, stainless steel appliances, and a dining area with wooden chairs and a table.
A kitchen with a stainless steel refrigerator, wooden ceiling fan, and a dining area with a table and chairs.
A covered porch with wicker furniture and a brick wall.
A living room with a wooden ceiling, a television, a green armchair, a sofa, and a coffee table.

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!

2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
Panacea
R2 591
per night
R10 169 total
includes taxes & fees
2 Mi to Mashes Sands Beach: Quiet Home w/ Dock!
A wooden dock with a metal bench and a covered seating area over a canal.
A room with a large window, a bench, a sofa, and a bed with patterned bedding.
A kitchen with white cabinets, a stainless steel refrigerator, a dishwasher, and a window with a view.
A modern kitchen with white cabinets, a wooden ceiling, and a yellow accent wall.

Waterfront Home: Spectacular On-site Fishing!

Waterfront Home: Spectacular On-site Fishing!
Panacea
R3 615
per night
R13 352 total
includes taxes & fees
Waterfront Home: Spectacular On-site Fishing!
A beach with wooden chairs and a table, overlooking the ocean.
A spacious living room with a large beige sectional sofa, a flat-screen TV mounted on the wall, and a ceiling fan.
A kitchen with a sink, countertop, and a view of the outside. There is a dining area with a table and chairs.
A kitchen with a dining table set for a meal, a hanging light fixture, and a view of the outdoors through large windows.

Waterfront Panacea Vacation Rental w/ Dock!

Waterfront Panacea Vacation Rental w/ Dock!
Panacea
R3 994
per night
R11 609 total
includes taxes & fees
Waterfront Panacea Vacation Rental w/ Dock!
A modern kitchen with a central island, bar stools, and pendant lighting.
A modern kitchen with a wooden table, stainless steel appliances, and a ceiling light fixture.
A wooden deck with a white railing, a covered porch area, and a view of palm trees and greenery.
A two-story house with a covered porch and a staircase leading to the upper level.

Nature Lover's Paradise: Hike, Bike & Fish!

Nature Lover's Paradise: Hike, Bike & Fish!
Panacea
R3 186
per night
R13 734 total
includes taxes & fees
Nature Lover's Paradise: Hike, Bike & Fish!
A two-car garage with wooden walls and a green exterior.
A modern kitchen with a central island, bar stools, stainless steel appliances, and a view of the outdoors.
A wooden boardwalk surrounded by lush green vegetation and tall trees.
A green building with a small outdoor sink and a window vent.

Breezy Home w/ Grills, Pool & Beach Access!

Breezy Home w/ Grills, Pool & Beach Access!
Panacea
R4 506
per night
R14 421 total
includes taxes & fees
Breezy Home w/ Grills, Pool & Beach Access!

Go beyond your typical stay in Panacea

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Pet friendly
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Spa
Spa
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Cottage
Cottage
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Family friendly
Family friendly
Our prices for hotels in Panacea are cheapest in February

Price trends for hotels in Panacea

Pricing is based on two traveller single night rates
View properties in October

October

High 27°C / low 18°C. Sunny most days.
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8°
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29°
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Monthly weather averages (˚C)

Top landmarks in Panacea

Alligator Point Beach

8.8/10 (10 reviews)
When the beach is calling your name, you might want to head down to Alligator Point Beach, located 4.5 mi (7.2 km) from central Alligator Point. Enjoy the sunset by the shore at Wilson Beach.
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Bald Point State Park

8.6/10 (20 reviews)
Bald Point State Park is 1.7 mi (2.7 km) from central Alligator Point, why not stop by during your stay?
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Mashes Sand Beach

8.8/10 (3 reviews)
If being by the water is a major draw, Mashes Sand Beach is a spot you might want to check out, located 5.1 mi (8.2 km) from central Panacea. If you want to continue walking by the waves, head to Shell Point Beach, Wilson Beach and Alligator Point Beach.
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beach near Alligator Point Marina

When the beach is calling your name, you might want to head down to beach near Alligator Point Marina, located 3 mi (4.8 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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Wilson Beach

Whether you want to collect beach glass or watch the sunset, Wilson Beach is a spot you might want to check out, located 7.4 mi (11.9 km) from central Panacea. Enjoy the sunset by the shore at Alligator Point Beach.
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beach near Alligator Point

When the beach is calling your name, you might want to head down to beach near Alligator Point, located 2.7 mi (4.4 km) from central Alligator Point. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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beach near Summer Camp Beach

Whether you want to collect beach glass or watch the sunset, beach near Summer Camp Beach is a spot you might want to check out, located 10.3 mi (16.6 km) from central Panacea. If you want to continue walking by the waves, head to Alligator Point Beach and Wilson Beach.
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Public Beach Access

Public Beach Access is 2.3 mi (3.7 km) from central Alligator Point, why not stop by during your stay? Want to stretch your legs a little more? Head to Alligator Harbor Aquatic Preserve, located nearby.
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Learn more about Panacea

Notable for its natural beauty, Panacea features attractions such as Mashes Sand Beach and Alligator Point Beach. This beachside city has something for everyone including seafood restaurants and sights like Bald Point State Park and Wilson Beach—all within a secluded setting.

See all hotels in Panacea
A coastal resort with beachfront villas and a clear blue sky.

Frequently Asked Questions

Can I book a refundable accommodation option in Panacea?

If you want the flexibility to change your plans to Panacea, most hotels offer refundable* rates that you can book. You can find this accommodation by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in Panacea if I want a holiday rental instead of a hotel?

If you're looking for a good alternative to a hotel, browse our selection of 177 holiday homes. In addition, there are 17 apartments and 10 condos.

What will the weather in Panacea be like during my visit?

July and August are typically the warmest months in Panacea, when the average temperature is 27°C. January and February are the coldest months, when the average temperature is 14°C. August and July are the months with the most rain.

Why should I book my Panacea hotel with Hotels.com?

There are lots of reasons to book your Panacea trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.