Hotels & Accommodation in Santa Cruz

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Check prices for these dates

Tonight

31 Oct - 01 Nov

Tomorrow

01 Nov - 02 Nov

Next weekend

06 Nov - 08 Nov

In two weeks

13 Nov - 15 Nov

Where to stay in Santa Cruz?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on quality, location and traveller experience. Last updated on 31 October 2026.

A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.

1. TRYP by Wyndham Santa Cruz

Equipetrol

R1 654 total

01 Nov - 02 Nov

A poolside area with lounge chairs and a palm tree.

2. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Equipetrol

R2 542 total

13 Nov - 14 Nov

A swimming pool with a water slide, surrounded by a hotel building with multiple floors and outdoor seating areas.

3. Hotel Cortez

Equipetrol

R2 166 total

08 Nov - 09 Nov

A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

4. Sun Hotel

Santa Cruz

R1 750 total

12 Nov - 13 Nov

A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.

5. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Santa Cruz

R1 230 total

07 Nov - 08 Nov

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

6. Camino Real Hotel

Santa Cruz

R2 406 total

01 Nov - 02 Nov

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

7. Ibis Santa Cruz DE LA Sierra

Equipetrol

R568 total

15 Nov - 16 Nov

A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

8. Lido Hotel

Centro Histórico

R411 total

02 Nov - 03 Nov

Breakfast area

9. Gran Hotel Mediterráneo

Centro Histórico

R914 total

01 Nov - 02 Nov

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

10. Cosmopolitano Hotel Boutique

Centro Histórico

R890 total

02 Nov - 03 Nov

A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

11. Marriott Santa Cruz de la Sierra Hotel

Santa Cruz

R2 059 total

07 Nov - 08 Nov

A swimming pool with a decorative center, surrounded by a building with a blue roof and a mural.

12. Gran Hotel Santa Cruz

Centro Histórico

R828 total

01 Nov - 02 Nov

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

13. Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 801 total

22 Nov - 23 Nov

A rooftop pool with clear skies and a city view.

14. Hotel Pascana centro

Centro Histórico

R1 278 total

02 Nov - 03 Nov

A hotel room with a large bed, bedside tables, a desk with a chair, a small refrigerator, and a TV mounted on the wall.

15. HOTEL OSHO

Santa Cruz

R733 total

01 Nov - 02 Nov

A high-rise hotel room with a large bathtub, two massage tables, and a city view.

16. Swissôtel Santa Cruz De La Sierra

Santa Cruz

R2 192 total

19 Nov - 20 Nov

A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

17. Premium Suites Deluxe Aparthotel Equipetrol

Santa Cruz

R769 total

01 Nov - 02 Nov

A spacious lobby with modern furniture, a high ceiling, and multiple hanging light fixtures.

18. Novotel Santa Cruz De La Sierra

Santa Cruz

R2 216 total

15 Nov - 16 Nov

A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

19. Hotel Las Américas

Centro Histórico

R434 total

09 Nov - 10 Nov

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

20. Chairú Eco Hotel

Santa Cruz

R790 total

10 Nov - 11 Nov

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A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

Cosmopolitano Hotel Boutique

Centro Histórico

per night

R1 852 total

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

Ibis Santa Cruz DE LA Sierra

Equipetrol

per night

R1 372 total

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 684 off

per night

R4 164 total

A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

Apart Hotel Premium Suites Santa Cruz

Santa Cruz

R100 off

per night

R902 total

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

Cosmopolitano Hotel Boutique

Centro Histórico

per night

R890 total

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

Ibis Santa Cruz DE LA Sierra

Equipetrol

per night

R596 total

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 123 off

per night

R1 801 total

A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

Apart Hotel Premium Suites Santa Cruz

Santa Cruz

R50 off

per night

R451 total

Check out pet-friendly hotels in Santa Cruz

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

Ibis Santa Cruz DE LA Sierra

Equipetrol

R568 total

15 Nov - 16 Nov

View all properties

You can also stay at hotels with a pool in Santa Cruz

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

Cosmopolitano Hotel Boutique

Centro Histórico

R890 total

02 Nov - 03 Nov

A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

Marriott Santa Cruz de la Sierra Hotel

Santa Cruz

R2 059 total

07 Nov - 08 Nov

A poolside area with lounge chairs and a palm tree.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Equipetrol

R2 542 total

13 Nov - 14 Nov

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 801 total

22 Nov - 23 Nov

A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

Premium Suites Deluxe Aparthotel Equipetrol

Santa Cruz

R769 total

01 Nov - 02 Nov

View all properties

Go beyond your typical stay in Santa Cruz

Pet friendly

Pool

Our prices for hotels in Santa Cruz are cheapest in February

Top neighbourhoods in Santa Cruz

Equipetrol

Santa Cruz's Equipetrol neighbourhood offers attractions, including Santa Cruz Zoo.

Centro Histórico

Santa Cruz's Centro Histórico neighbourhood is home to attractions, such as Plaza 24 de Septiembre and La Recova Artisan Walk.

Hamacas

Zona Sur (South Zone)

Urubó

Top landmarks in Santa Cruz

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)

If you're planning a bit of sightseeing, head to Plaza 24 de Septiembre – just one of the monuments in Centro Histórico.

Learn more about Santa Cruz

Santa Cruz is applauded for its cultural attractions such as Ethno-folkloric Museum and Cine Center.

See all hotels in Santa Cruz

A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.

Check out reviews of Santa Cruz hotels guests love

Camino Real Hotel

Camino Real Hotel

8/10 Good

"Muy bueno"

Hotel Cortez

Hotel Cortez

10/10 Excellent

"El hotel es fantastico, el desayuno excelente, los servicios que brinda el hotel son un plus para el huésped. En general, el personal es atento y amable. Sin embargo, tuvimos problemas en el check in, la señorita que nos recibió indicó que no teníamos reservación. Se le indicó que la reservación se había hecho por Expedia y ella insistió en que no teníamos alguna. Cuando llamé a Expedia, nos dijo que, aunque el hotel estaba lleno, nos darían una habitación. Esta señorita parece no ser tan amable, lo cual es la excepción, pues el personal es atento y presto a ayudar al huésped."

Frequently asked questions

Can I book a refundable accommodation option in Santa Cruz?

If you want the flexibility to change your plans to Santa Cruz, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Santa Cruz if I want a holiday rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 23 holiday homes. In addition, you can choose from 198 apartments.

What will the weather in Santa Cruz be like during my visit?

Santa Cruz is a great place to visit to enjoy the sunshine at any time of year, with an average temp of 21°C.

Why should I book my Santa Cruz hotel with Hotels.com?

There are lots of reasons to book your Santa Cruz trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

Find out more about Santa Cruz

Santa Cruz: A Vibrant Tapestry of Nature's Blooms and Architectural Wonders

Nestled in the heart of Bolivia, Santa Cruz captivates with its vibrant cityscape, lush floral displays, and the majestic Cathedral that graces its skyline. Embracing Bolivian hospitality, visitors can savour the charm of central Santa Cruz and its rich cultural heritage, making it a perfect destination for a memorable next stay. Experience the blend of modern life and traditional splendour in this dynamic city.

Discover great hotels near Santa Cruz

Santa Cruz, Santa Cruz, Bolivia offers a range of hotels from cosy, comfortable stays to luxurious options, often rated up to five stars. Ideal accommodations come with modern amenities, welcoming lounges and elegant dining areas, ensuring a pleasant stay for travellers. Here are some of the most popular hotels with our travelers near Santa Cruz:

Hotel Rio Selva Resort Santa CruzOpens in a new window: This 3.0-star hotel offers travellers a comfortable and inviting experience, highlighted by its thoughtfully curated amenities for children including a free crib, shared playground, supervised childcare on site, a child-friendly pool, and on-site babysitting childcare. Ideal for leisure travellers seeking a relaxed and family-friendly retreat, the property provides a welcoming atmosphere and smooth service throughout your stay.
Novotel Santa Cruz De La SierraOpens in a new window: This 5.0-star hotel boasts an impressive guest rating and a luxurious setting tailored for leisure travellers. Guests can indulge in high-end experiences with standout features such as a rooftop bar, spa, infinity pool, express check-in, and curated high-quality amenities. The property offers an atmosphere of elegant design and premium comfort, ensuring a distinctive and memorable journey.
Marriott Santa Cruz de la Sierra HotelOpens in a new window: This 5.0-star hotel, with an outstanding guest rating, dazzles leisure travellers with its luxurious and boutique ambiance. Highlighting a range of curated experiences, guests can enjoy high-end offerings such as an infinity pool, rooftop bar, spa, high-end restaurant, and express check-in. The property exudes a refined architectural design and a smooth service, promising a journey filled with premium comfort and top-tier amenities.

4 tips for savvy savings when booking a hotel in Santa Cruz

Book for the cheapest times: The most affordable time to visit Santa Cruz is from June to August, when hotel prices are lower. For an enriching experience, it's recommended to stay for at least 3 to 4 days to thoroughly enjoy the city's key landmarks and cultural sites. During your visit, you can explore charming cafes, indulge in shopping, admire the local flora, visit the zoo, and partake in excursions centred around the area's history. Additionally, there are opportunities for birdwatching and enjoying local soccer matches, all of which provide great value for money while travelling on a budget. As a bonus, prices may drop during this period, making it an even more budget-friendly option for your getaway.
Look for last-minute deals on Hotels.com: To discover last-minute deals to Santa Cruz, visit the DealsOpens in a new window or Last-Minute Deals section on Hotels.com, where you may find discounted hotel options as your travel date approaches. You could also enable email alerts or push notifications from Hotels.com to stay updated on flash sales and exclusive promotions, helping you seize any opportunities to save. Additionally, Smart Shopping is a useful tool within the app that allows you to compare hotel prices and amenities, ensuring you’re informed if prices drop or rooms become available, making your last-minute getaway even more accessible.
Be flexible with dates: Prices may vary depending on factors such as the hotel's location, star rating, and time of year, so remaining flexible with your dates could help you save on your stay in a Santa Cruz hotel. For those seeking unique experiences, boutique hotels may offer a more personalised experience and occasionally better value. When you book with Hotels.com, we will inform you if the price for your selected dates is above or below the average, and if it appears to be on the higher side, we might suggest more affordable dates to help you find a better deal.
Consider your location: Hotels situated near the city centre generally tend to be more expensive, but with Santa Cruz's excellent public transport connections, you may discover a more affordable independent hotel further afield that remains well-connected. For those keen to explore alternative, less crowded neighbourhoods or even lesser-known nearby towns, there is often great value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Santa Cruz

Santa Cruz experiences its lowest average temperature in June, at 67.8°F (19.9°C), while October is the hottest month, with an average temperature of 79.5°F (26.4°C). January is typically the wettest month. If you’re looking to soak up the lively atmosphere in Santa Cruz, January, July, and September are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is sunny to mostly sunny, with little to no rainfall. However, if you prefer a more relaxed experience, May, October, and December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

Keep exploring

Accommodation

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