Hotels & Accommodation in Santa Cruz

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
14 Nov - 15 Nov
Tomorrow
15 Nov - 16 Nov
Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov

Where to stay in Santa Cruz?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on quality, location and traveller experience. Last updated on 14 November 2026.
A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.

1. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Equipetrol
9.2 out of 10, Wonderful, (186 reviews)
Immerse in Santa Cruz's vibrant scene at this Art Deco haven with a refreshing outdoor pool and relaxing sauna. Just minutes from Patio Design LifeStyle Centre and the Zoo, enjoy complimentary breakfast, WiFi, and parking after a day of exploration.
The price is R1 173
R1 173 total
15 Nov - 16 Nov
TRYP by Wyndham Santa Cruz
A spacious lobby with high ceilings, wooden beams, and a large seating area with wicker chairs.

2. Hotel Cortez

Hotel Cortez
3.5 star property
Equipetrol
9.4 out of 10, Exceptional, (163 reviews)
The price is R2 194
R2 194 total
15 Nov - 16 Nov
Hotel Cortez
A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

3. Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (457 reviews)
Set in a prime Santa Cruz location, this luxurious hotel features indoor and outdoor pools, 2 bars, and a full-service spa offering massages. La Tranquera restaurant serves daily meals, with Ventura Mall and Santa Cruz Zoo nearby for exploration.
The price is R1 989
R1 989 total
15 Nov - 16 Nov
Camino Real Hotel
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.

4. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (295 reviews)
Upscale retreat with a Roof Top Bar & Lounge serving three daily meals and stunning city views. Free breakfast, WiFi and parking complement the fitness centre. Ventura Mall and Patio Design LifeStyle Centre wait just minutes away.
The price is R1 246
R1 246 total
21 Nov - 22 Nov
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A resort with a central swimming pool surrounded by lounge areas, palm trees, and multiple high-rise buildings in the background.

5. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
5.0 star property
Equipetrol
9.0 out of 10, Wonderful, (428 reviews)
A sophisticated retreat in Santa Cruz featuring spa services with massages and facials. Two restaurants serving international cuisine complement the fitness centre and hot tub. Near Patio Design LifeStyle Centre and Ventura Mall with convenient airport access.
The price is R2 720
R2 720 total
21 Nov - 22 Nov
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
A nighttime view of a hotel pool area with palm trees and a bench.

6. Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.2 out of 10, Very good, (419 reviews)
Relax at this convenient hotel just 2 mi from Viru Viru International Airport with 24-hour free shuttle service. Enjoy the outdoor pool, fitness centre, and rejuvenating massages after visiting Play Land Amusement Park nearby.
The price is R1 783
R1 783 total
15 Nov - 16 Nov
Sun Hotel
A staircase with ornate lion statues at the base, a chandelier, and a framed artwork on the wall.

7. Lido Hotel

Lido Hotel
3.0 star property
Centro Histórico
9.2 out of 10, Wonderful, (58 reviews)
This Santa Cruz hotel offers a convenient base with complimentary breakfast, WiFi, and parking. Explore nearby Arenal Park and the Ethno-folkloric Museum, then return for a comfortable stay. The Viru Viru Airport is just 27 minutes away.
The price is R432
R432 total
15 Nov - 16 Nov
Lido Hotel
A modern lounge area with sofas, tables, and potted plants.

8. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Equipetrol
9.4 out of 10, Exceptional, (159 reviews)
Discover Santa Cruz from this modern hotel with a bar, café, and business-friendly amenities. Located near Municipal Library and Patio Design LifeStyle Centre, enjoy free WiFi and parking while the helpful staff ensures a pleasant stay.
The price is R713
R713 total
04 Dec - 05 Dec
Ibis Santa Cruz DE LA Sierra
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

9. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (261 reviews)
Set in Santa Cruz with international dining at Toborochi restaurant, this luxury hotel offers relaxing massages at the spa. Cool off in the outdoor pool, work out in the fitness centre, or enjoy a drink at the bar after exploring nearby Ventura Mall.
The price is R1 943
R1 943 total
28 Nov - 29 Nov
Marriott Santa Cruz de la Sierra Hotel
A modern hotel with a tall tower, multiple floors, and a surrounding lush green landscape.

10. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (91 reviews)
Immerse yourself in this entertainment district gem near Ventura Mall. Unwind at the full-service spa, cool off in the outdoor pool with cocktails from the poolside bar, or dine at the restaurant after exploring Santa Cruz Zoo.
The price is R2 221
R2 221 total
04 Dec - 05 Dec
Swissôtel Santa Cruz De La Sierra
A multi-level indoor space with a pool, wooden flooring, and potted plants.

11. Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140 reviews)
Slip into holiday mode at this boutique retreat with an outdoor pool and poolside bar. Near Sacred Art Museum and Franco Aleman Cultural Centre, the hotel offers free breakfast, WiFi, and parking. Massages add extra bliss after exploring the area.
The price is R980
R980 total
29 Nov - 30 Nov
Cosmopolitano Hotel Boutique
A multi-level atrium with a central planter containing various plants, surrounded by glass railings and a brick wall.

12. Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (81 reviews)
Immerse in eco-conscious luxury at this Santa Cruz retreat offering 2 on-site dining options and a relaxed bar/lounge. Explore nearby Ventura Mall and Patio Design LifeStyle Centre, then unwind with complimentary WiFi and attentive 24-hour service.
The price is R800
R800 total
15 Nov - 16 Nov
Chairú Eco Hotel
A modern hotel building with a glass facade and a sign that reads 'OSHO HOTEL'.

13. HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (61 reviews)
Immerse in serenity at this welcoming retreat featuring a full-service spa, outdoor pool, and hot tub. Just minutes from Santa Cruz's Contemporary Art Museum, enjoy complimentary breakfast and WiFi after exploring nearby cultural attractions.
The price is R743
R743 total
15 Nov - 16 Nov
HOTEL OSHO
An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.

14. Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Equipetrol
9.6 out of 10, Exceptional, (51 reviews)
Bask in the Bolivian sunshine at the outdoor pool before enjoying a cocktail at the bar. Minutes from Santa Cruz Zoo and free breakfast, parking, and WiFi elevate your stay at this fitness-equipped retreat.
The price is R1 846
R1 846 total
27 Nov - 28 Nov
Alfonsina Hotel Boutique by Inboccaluppo
A swimming pool area with lounge chairs and a covered seating area, surrounded by greenery and modern architecture.

15. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (134 reviews)
This luxurious Santa Cruz hotel offers both outdoor and children's pools plus a hot tub for relaxation. Kids stay entertained at the free club while adults unwind at the bar. Near Parque Ecológico with free breakfast, WiFi, and parking.
The price is R2 245
R2 245 total
04 Dec - 05 Dec
Novotel Santa Cruz De La Sierra
A hotel room with a bed, bedside table, and a glass table with a vase of flowers.

16. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (121 reviews)
The price is R771
R771 total
26 Nov - 27 Nov
Premium Suites Deluxe Aparthotel Equipetrol
A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

17. Hotel Las Américas

Hotel Las Américas
3.0 star property
Centro Histórico
7.8 out of 10, Good, (36 reviews)
This Santa Cruz hotel offers complimentary buffet breakfast daily and free WiFi to enhance your stay. Located near La Recova Artisan Walk and Guarani Nandereko Nomai Art and Culture Centre, with 24-hour front desk service for round-the-clock assistance.
The price is R442
R442 total
15 Nov - 16 Nov
Hotel Las Américas
A hotel room with a bed, a desk, a TV, and a large window with a cityscape view.

18. Hotel Pascana centro

Hotel Pascana centro
3.5 star property
Centro Histórico
9.4 out of 10, Exceptional, (3 reviews)
The price is R1 295
R1 295 total
16 Nov - 17 Nov
Hotel Pascana centro
A modern hotel with a pool area, featuring a cylindrical water feature and multiple balconies.

19. Hotel Arenal

Hotel Arenal
3.5 star property
Centro Histórico
7.6 out of 10, Good, (65 reviews)
Escape to this tranquil retreat offering 2 outdoor pools and a poolside bar where relaxation flows freely. Just minutes from Arenal Park and the Ethno-folkloric Museum, this hotel provides free breakfast and convenient airport access.
The price is R1 079
R1 079 total
24 Nov - 25 Nov
Hotel Arenal
Room

20. Hotel Maywa

Hotel Maywa
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (10 reviews)
The price is R757
R757 total
15 Nov - 16 Nov
Hotel Maywa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Get last-minute hotel deals in Santa Cruz and save more

Sign in to unlock great savings.
Showing deals for:20 Nov - 22 Nov
A multi-level indoor space with a pool, wooden flooring, and potted plants.
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140 reviews)
The price is R1 068
per night
R2 136 total
MOD
Sign in for extra savings
Cosmopolitano Hotel Boutique
Showing deals for:14 Dec - 15 Dec
A multi-level indoor space with a pool, wooden flooring, and potted plants.
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140 reviews)
R340 off
The price is R1 020
per night
R1 020 total
Cosmopolitano Hotel Boutique

Check out pet-friendly hotels in Santa Cruz

A multi-level indoor space with a pool, wooden flooring, and potted plants.
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140)
The price is R980
R980 total
29 Nov - 30 Nov
Cosmopolitano Hotel Boutique
View all properties

You can also stay at hotels with a pool in Santa Cruz

A multi-level indoor space with a pool, wooden flooring, and potted plants.
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Centro Histórico
9.2 out of 10, Wonderful, (140)
The price is R980
R980 total
29 Nov - 30 Nov
Cosmopolitano Hotel Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Go beyond your typical stay in Santa Cruz

Pool image
Pool
Pool
hot tub image
Hot tub
Hot tub

When is the best time to visit Santa Cruz?

Our prices for hotels in Santa Cruz are cheapest in February

Price trends for hotels in Santa Cruz

Pricing is based on two traveller single night rates
View properties in November
Currently viewing crowd sizes and weather for November.

November

High 32°C / low 22°C. Sunny most days.
32°
weather_sun
November, no crowd data, average high temperature 32 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
22°
31°
weather_sun
December, no crowd data, average high temperature 31 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
22°
31°
weather_sun
January, no crowd data, average high temperature 31 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
22°
29°
weather_cloudy
February, no crowd data, average high temperature 29 degrees Celsius, average low temperature 22 degrees Celsius. Cloudy most days.
22°
29°
weather_sun
March, no crowd data, average high temperature 29 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
28°
weather_sun
April, no crowd data, average high temperature 28 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
25°
weather_sun
May, no crowd data, average high temperature 25 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
24°
weather_sun
June, no crowd data, average high temperature 24 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
25°
weather_sun
July, no crowd data, average high temperature 25 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
28°
weather_sun
August, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
31°
weather_sun
September, no crowd data, average high temperature 31 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
32°
weather_sun
October, no crowd data, average high temperature 32 degrees Celsius, average low temperature 22 degrees Celsius. Sunny most days.
22°
Monthly weather averages (˚C)

Top neighbourhoods in Santa Cruz

Equipetrol

Santa Cruz's Equipetrol neighbourhood offers attractions, including Santa Cruz Zoo.

Centro Histórico

Santa Cruz's Centro Histórico neighbourhood is home to attractions, such as Plaza 24 de Septiembre and La Recova Artisan Walk.

Top landmarks in Santa Cruz

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
If you're planning a bit of sightseeing, head to Plaza 24 de Septiembre – just one of the monuments in Centro Histórico.
See properties

Learn more about Santa Cruz

Santa Cruz is applauded for its cultural attractions such as Ethno-folkloric Museum and Cine Center.

See all hotels in Santa Cruz
A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.

Frequently Asked Questions

Can I book a refundable accommodation option in Santa Cruz?

If you want the flexibility to change your plans to Santa Cruz, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Santa Cruz if I want a holiday rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 23 holiday homes. In addition, you can choose from 198 apartments.

What will the weather in Santa Cruz be like during my visit?

Santa Cruz is a great place to visit to enjoy the sunshine at any time of year, with an average temp of 21°C.

Why should I book my Santa Cruz hotel with Hotels.com?

There are lots of reasons to book your Santa Cruz trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

Find out more about Santa Cruz

Santa Cruz: A Vibrant Tapestry of Nature's Blooms and Architectural Wonders

Nestled in the heart of Bolivia, Santa Cruz captivates with its vibrant cityscape, lush floral displays, and the majestic Cathedral that graces its skyline. Embracing Bolivian hospitality, visitors can savour the charm of central Santa Cruz and its rich cultural heritage, making it a perfect destination for a memorable next stay. Experience the blend of modern life and traditional splendour in this dynamic city.

Discover great hotels near Santa Cruz

Santa Cruz, Santa Cruz, Bolivia offers a range of hotels from cosy, comfortable stays to luxurious options, often rated up to five stars. Ideal accommodations come with modern amenities, welcoming lounges and elegant dining areas, ensuring a pleasant stay for travellers. Here are some of the most popular hotels with our travelers near Santa Cruz:

  1. Hotel Rio Selva Resort Santa Cruzopens in new window: This 3.0-star hotel offers travellers a comfortable and inviting experience, highlighted by its thoughtfully curated amenities for children including a free crib, shared playground, supervised childcare on site, a child-friendly pool, and on-site babysitting childcare. Ideal for leisure travellers seeking a relaxed and family-friendly retreat, the property provides a welcoming atmosphere and smooth service throughout your stay.
  2. Novotel Santa Cruz De La Sierraopens in new window: This 5.0-star hotel boasts an impressive guest rating and a luxurious setting tailored for leisure travellers. Guests can indulge in high-end experiences with standout features such as a rooftop bar, spa, infinity pool, express check-in, and curated high-quality amenities. The property offers an atmosphere of elegant design and premium comfort, ensuring a distinctive and memorable journey.
  3. Marriott Santa Cruz de la Sierra Hotelopens in new window: This 5.0-star hotel, with an outstanding guest rating, dazzles leisure travellers with its luxurious and boutique ambiance. Highlighting a range of curated experiences, guests can enjoy high-end offerings such as an infinity pool, rooftop bar, spa, high-end restaurant, and express check-in. The property exudes a refined architectural design and a smooth service, promising a journey filled with premium comfort and top-tier amenities.

4 tips for savvy savings when booking a hotel in Santa Cruz

  1. Book for the cheapest times: The most affordable time to visit Santa Cruz is from June to August, when hotel prices are lower. For an enriching experience, it's recommended to stay for at least 3 to 4 days to thoroughly enjoy the city's key landmarks and cultural sites. During your visit, you can explore charming cafes, indulge in shopping, admire the local flora, visit the zoo, and partake in excursions centred around the area's history. Additionally, there are opportunities for birdwatching and enjoying local soccer matches, all of which provide great value for money while travelling on a budget. As a bonus, prices may drop during this period, making it an even more budget-friendly option for your getaway.
  2. Look for last-minute deals on Hotels.com: To discover last-minute deals to Santa Cruz, visit the Dealsopens in new window or Last-Minute Deals section on Hotels.com, where you may find discounted hotel options as your travel date approaches. You could also enable email alerts or push notifications from Hotels.com to stay updated on flash sales and exclusive promotions, helping you seize any opportunities to save. Additionally, Smart Shopping is a useful tool within the app that allows you to compare hotel prices and amenities, ensuring you’re informed if prices drop or rooms become available, making your last-minute getaway even more accessible.
  3. Be flexible with dates: Prices may vary depending on factors such as the hotel's location, star rating, and time of year, so remaining flexible with your dates could help you save on your stay in a Santa Cruz hotel. For those seeking unique experiences, boutique hotels may offer a more personalised experience and occasionally better value. When you book with Hotels.com, we will inform you if the price for your selected dates is above or below the average, and if it appears to be on the higher side, we might suggest more affordable dates to help you find a better deal.
  4. Consider your location: Hotels situated near the city centre generally tend to be more expensive, but with Santa Cruz's excellent public transport connections, you may discover a more affordable independent hotel further afield that remains well-connected. For those keen to explore alternative, less crowded neighbourhoods or even lesser-known nearby towns, there is often great value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Santa Cruz

Santa Cruz experiences its lowest average temperature in June, at 67.8°F (19.9°C), while October is the hottest month, with an average temperature of 79.5°F (26.4°C). January is typically the wettest month. If you’re looking to soak up the lively atmosphere in Santa Cruz, January, July, and September are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is sunny to mostly sunny, with little to no rainfall. However, if you prefer a more relaxed experience, May, October, and December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.