Hotels & Accommodation in Santa Cruz

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Check prices for these dates

Tonight

05 Sept - 06 Sept

Tomorrow

06 Sept - 07 Sept

Next weekend

11 Sept - 13 Sept

In two weeks

18 Sept - 20 Sept

Where to stay in Santa Cruz?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on quality, location and traveller experience. Last updated on 05 September 2026.

A poolside area with lounge chairs and a palm tree.

A banquet hall with long tables, chandeliers, and draped curtains.

A pathway through a lush garden with various trees and shrubs.

A dining table with breakfast items and a pool view.

1. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Santa Cruz

R2 292

R2 292 total

13 Sept - 14 Sept

A buffet setup with various food items and beverages.

A hotel reception area with a modern design, featuring a reception desk, seating area, and a wall with various artworks.

A corridor with wooden doors, orange walls, and a carpeted floor.

A modern hotel room with a large bed, a desk, a chair, and a view of the outside.

2. Hotel LP Equipetrol

Santa Cruz

R577

R657 total

06 Sept - 07 Sept

A spacious lobby with large windows, modern chandeliers, and a seating area with sofas and chairs.

A spacious lobby with a high ceiling, modern furniture, and a central seating area.

A nighttime pool area with a blue-lit water surface, palm trees, and a modern building with geometric light patterns in the background.

A window seat with a view of a cityscape at dusk.

3. Novotel Santa Cruz De La Sierra

Santa Cruz

R1 972

R1 972 total

01 Oct - 02 Oct

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

A spacious lobby with high ceilings, large windows, and a modern chandelier.

A large, illuminated swimming pool surrounded by palm trees and pathways.

A restaurant with a long counter, dark chairs, and hanging lights.

4. Camino Real Hotel

Santa Cruz

R2 315

R2 315 total

14 Sept - 15 Sept

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

A spacious lobby with a brick accent wall, a seating area with a coffee table, and a view of the kitchen in the background.

A multi-level atrium with a central planter containing various plants, surrounded by glass railings and a brick wall.

A room with a large window, a brick wall, and a hanging plant.

5. Chairú Eco Hotel

Santa Cruz

R898

R898 total

06 Sept - 07 Sept

A swimming pool with a water slide, surrounded by a hotel building with multiple floors and outdoor seating areas.

A buffet with various fruits and snacks.

A spacious lobby with high ceilings, wooden beams, and a large seating area with wicker chairs.

A high-rise hotel with multiple floors, a swimming pool, and a well-lit street with cars.

6. Hotel Cortez

Santa Cruz

R1 953

R1 953 total

06 Sept - 07 Sept

A modern lobby with seating areas, a coffee table, and a large potted plant.

A modern dining area with green chairs, a long table, and a wall with geometric patterns.

A modern hotel with multiple floors, large windows, and a prominent red sign on the facade.

A hotel interior with a modern design, featuring a large window with a view of palm trees and a sign that reads "ibis HOTEL". There are three green chairs and a small round table.

7. Ibis Santa Cruz DE LA Sierra

Santa Cruz

R696

R696 total

11 Sept - 12 Sept

A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

A luxurious banquet hall with ornate chandeliers, floral arrangements, and elegant table settings.

A restaurant with a high ceiling, large windows, and a view of the cityscape. Tables are set with plates, glasses, and cutlery.

A modern lobby with a dining area, sofas, and a decorative wall.

8. Marriott Santa Cruz de la Sierra Hotel

Santa Cruz

R1 693

R1 693 total

02 Oct - 03 Oct

A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

A modern staircase with glass railings, leading to a landing with a small garden area.

A modern lobby with wooden paneling, two grey sofas, and pendant lighting.

A hotel room with a large bed, a TV mounted on the wall, a dining area with chairs, and a sofa.

9. Premium Suites Deluxe Aparthotel Equipetrol

Santa Cruz

R734

R734 total

07 Sept - 08 Sept

A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

A spacious lobby with a curved reception desk, multiple seating areas, and a bar.

A table set for a meal with a view of a body of water and decorative lighting.

A spacious indoor area with multiple dining tables and chairs, a staircase, and large windows offering a view of the outdoors.

10. Sun Hotel

Santa Cruz

R1 867

R1 867 total

06 Sept - 07 Sept

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

A modern outdoor pool area with a red brick wall, a large mural, and outdoor furniture.

A long bar with a wooden countertop, shelves with glassware, and framed pictures on the wall.

An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.

11. Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 720

R1 720 total

11 Sept - 12 Sept

A spacious room with a wooden floor and large windows offering a city view.

A buffet table with various food items and a wine bottle.

A modern gym with a treadmill, a glass table with fitness items, and a city view through large windows.

A hotel room with two beds, a nightstand, and a wall-mounted lamp.

12. Swissôtel Santa Cruz De La Sierra

Santa Cruz

R2 617

R2 617 total

20 Sept - 21 Sept

A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.

A modern lounge area with leather sofas, a coffee table, and a view of a green wall with plants.

A reception area with a marble counter, a large chandelier, and a digital display.

A rooftop pool area with a view of the city skyline at dusk.

13. TRYP by Wyndham Santa Cruz

Santa Cruz

R1 739

R1 739 total

06 Sept - 07 Sept

A rooftop pool with a glass barrier reflecting the sunset and city skyline.

A modern building with a stone facade and large windows. The name 'DEFINES COLLECTION' is prominently displayed on the building.

A hotel room with two beds, a desk, and a view of the city.

An outdoor dining area with tables and chairs, a wooden pergola with hanging lights, and a city view.

14. Delfines Collection Hotel By Mercure

Santa Cruz

R804

R804 total

10 Sept - 11 Sept

A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.

A modern hotel lobby with a bar area, seating arrangements, and a television.

A small, enclosed garden area with various potted plants and a gravel path.

A hotel room with a large bed, a desk, a chair, a telephone, and a view of the city through large windows.

15. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Santa Cruz

R1 175

R1 175 total

02 Oct - 03 Oct

A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

A buffet setup with various food items and a serving area.

A hotel room with two beds, a desk, a television, and a small kitchenette.

A hotel with a unique wavy facade, multiple parking spaces, and a clear blue sky.

16. Hotel Las Américas

Santa Cruz

R417

R417 total

06 Sept - 07 Sept

A hotel room with a large bed, a desk with a computer, a chair, and a painting on the wall.

A modern interior with a dining area, kitchen, and large windows.

A room with a glass table and chair, a lamp, and a view of a brick building through large windows.

A compact kitchenette with a refrigerator, a coffee maker, and a small table with a laptop.

17. Hotel Pascana centro

Centro Histórico

R879

R879 total

06 Sept - 07 Sept

A modern hotel room with a large bed, bedside tables, a desk with a chair, a small fridge, and a TV mounted on the wall.

A hotel room with two beds, a sofa, a TV, and a wall-mounted light fixture.

A paved outdoor area with a row of chairs, a planter with large-leafed plants, and a staircase leading to a higher level.

18. HOTEL OSHO

Santa Cruz

R872

R872 total

01 Oct - 02 Oct

A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

A traditional-style room with a sofa set, a table, and two chairs.

Wicker furniture with cushions, potted plants, and a ceiling with lights.

A staircase with ornate lion statues at the base, a chandelier, and a framed artwork on the wall.

19. Lido Hotel

Centro Histórico

R382

R382 total

07 Sept - 08 Sept

A room with a red sofa, a small black table, and a wooden door.

A grand staircase with ornate railings, marble flooring, and a seating area with purple armchairs.

A hotel room with two beds, a desk with a lamp, a chair, and a large window with curtains.

A hotel room with a bed, a desk, a chair, a table, a TV, and a mirror.

20. Gran Hotel Santa Cruz

Centro Histórico

R827

R935 total

07 Sept - 08 Sept

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A modern lobby with seating areas, a coffee table, and a large potted plant.

A modern dining area with green chairs, a long table, and a wall with geometric patterns.

A modern hotel with multiple floors, large windows, and a prominent red sign on the facade.

A hotel interior with a modern design, featuring a large window with a view of palm trees and a sign that reads "ibis HOTEL". There are three green chairs and a small round table.

Ibis Santa Cruz DE LA Sierra

Santa Cruz

R696

per night

R1 392 total

A swimming pool with a water slide, surrounded by a hotel building with multiple floors and outdoor seating areas.

A buffet with various fruits and snacks.

A spacious lobby with high ceilings, wooden beams, and a large seating area with wicker chairs.

A high-rise hotel with multiple floors, a swimming pool, and a well-lit street with cars.

Hotel Cortez

Santa Cruz

R1 953

per night

R3 907 total

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

A spacious lobby with a brick accent wall, a seating area with a coffee table, and a view of the kitchen in the background.

A multi-level atrium with a central planter containing various plants, surrounded by glass railings and a brick wall.

A room with a large window, a brick wall, and a hanging plant.

Chairú Eco Hotel

Santa Cruz

R598 off

R898

per night

R1 795 total

A buffet setup with various food items and beverages.

A hotel reception area with a modern design, featuring a reception desk, seating area, and a wall with various artworks.

A corridor with wooden doors, orange walls, and a carpeted floor.

A modern hotel room with a large bed, a desk, a chair, and a view of the outside.

Hotel LP Equipetrol

Santa Cruz

R1 569 off

R671

per night

R1 422 total

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

A spacious lobby with high ceilings, large windows, and a modern chandelier.

A large, illuminated swimming pool surrounded by palm trees and pathways.

A restaurant with a long counter, dark chairs, and hanging lights.

Camino Real Hotel

Santa Cruz

R3 335 off

R2 839

per night

R5 679 total

A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

A traditional-style room with a sofa set, a table, and two chairs.

Wicker furniture with cushions, potted plants, and a ceiling with lights.

A staircase with ornate lion statues at the base, a chandelier, and a framed artwork on the wall.

Lido Hotel

Centro Histórico

R85 off

R382

per night

R763 total

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

A multi-level indoor space with a pool, wooden flooring, and potted plants.

A rooftop pool area with a glass balustrade, wooden deck, and a seating area with cushions and a small table.

A room with a bed, a small wooden stool, a potted plant in a black frame, and a door in the background.

Cosmopolitano Hotel Boutique

Santa Cruz

R711 off

R1 067

per night

R2 134 total

A hotel room with a large window, a desk with a chair, a bed with white bedding and a blue accent, and a TV mounted on the wall.

A hotel entrance with glass doors, a sign reading "LP HOTELES", and a green wall.

A modern restaurant interior with high tables and chairs, a large window with a view of the city, and a mural of a pink cherry blossom tree.

A modern lobby with a glass wall, a blue sofa, a glass table, and a patterned ottoman.

Hotel LP Santa Cruz Centro

Santa Cruz

R603 off

R641

per night

R1 361 total

A modern hotel room with a large bed, bedside tables, a desk with a chair, a small fridge, and a TV mounted on the wall.

A hotel room with two beds, a sofa, a TV, and a wall-mounted light fixture.

A paved outdoor area with a row of chairs, a planter with large-leafed plants, and a staircase leading to a higher level.

HOTEL OSHO

Santa Cruz

R429 off

R934

per night

R1 869 total

A modern rooftop pool with a city view, wooden flooring, and a seating area.

A modern kitchen with a built-in grill, a black countertop, and a wall mural of tropical leaves.

A modern hotel room with a bed, bedside table, and a desk with a chair.

A modern office space with a dark wood desk, a black office chair, a flat-screen TV mounted on the wall, and an air conditioning unit.

AMERICA APARTMENTS

Santa Cruz

R158 off

R711

per night

R1 422 total

A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

A buffet setup with various food items and a serving area.

A hotel room with two beds, a desk, a television, and a small kitchenette.

A hotel with a unique wavy facade, multiple parking spaces, and a clear blue sky.

Hotel Las Américas

Santa Cruz

R93 off

R417

per night

R833 total

A hotel sign with the text "Apart Hotel Premium Suites Santa Cruz".

A balcony with two wooden chairs and a table, overlooking a cityscape with various buildings.

A dining area with a glass table, metal chairs, and a buffet setup. There is a red sofa in the living area and a kitchen in the background.

A reception desk with a wooden panel wall behind it, displaying the text "Premium Suites".

Apart Hotel Premium Suites Santa Cruz

Santa Cruz

R96 off

R431

per night

R862 total

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

A modern outdoor pool area with a red brick wall, a large mural, and outdoor furniture.

A long bar with a wooden countertop, shelves with glassware, and framed pictures on the wall.

An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 631 off

R1 977

per night

R3 954 total

A modern bedroom with a bed, bedside table, and a desk with a laptop.

A modern kitchen with a wooden countertop, various appliances, and a dining area with chairs and a table.

A modern bathroom with a glass shower, a potted plant, and a towel rack.

A modern bathroom with a glass shower enclosure, a potted plant, a towel rack, and a black countertop.

Hotel G

Santa Cruz

R163 off

R461

per night

R923 total

Prince Hotel

Santa Cruz

R172 off

R776

per night

R1 615 total

A modern lobby with seating areas, a coffee table, and a large potted plant.

A modern dining area with green chairs, a long table, and a wall with geometric patterns.

A modern hotel with multiple floors, large windows, and a prominent red sign on the facade.

A hotel interior with a modern design, featuring a large window with a view of palm trees and a sign that reads "ibis HOTEL". There are three green chairs and a small round table.

Ibis Santa Cruz DE LA Sierra

Santa Cruz

R801

per night

R801 total

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

A multi-level indoor space with a pool, wooden flooring, and potted plants.

A rooftop pool area with a glass balustrade, wooden deck, and a seating area with cushions and a small table.

A room with a bed, a small wooden stool, a potted plant in a black frame, and a door in the background.

Cosmopolitano Hotel Boutique

Santa Cruz

R293 off

R878

per night

R878 total

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

A spacious lobby with a brick accent wall, a seating area with a coffee table, and a view of the kitchen in the background.

A multi-level atrium with a central planter containing various plants, surrounded by glass railings and a brick wall.

A room with a large window, a brick wall, and a hanging plant.

Chairú Eco Hotel

Santa Cruz

R299 off

R898

per night

R898 total

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.

A spacious lobby with high ceilings, large windows, and a modern chandelier.

A large, illuminated swimming pool surrounded by palm trees and pathways.

A restaurant with a long counter, dark chairs, and hanging lights.

Camino Real Hotel

Santa Cruz

R2 573

per night

R2 573 total

A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

A traditional-style room with a sofa set, a table, and two chairs.

Wicker furniture with cushions, potted plants, and a ceiling with lights.

A staircase with ornate lion statues at the base, a chandelier, and a framed artwork on the wall.

Lido Hotel

Centro Histórico

R42 off

R382

per night

R382 total

A swimming pool with a water slide, surrounded by a hotel building with multiple floors and outdoor seating areas.

A buffet with various fruits and snacks.

A spacious lobby with high ceilings, wooden beams, and a large seating area with wicker chairs.

A high-rise hotel with multiple floors, a swimming pool, and a well-lit street with cars.

Hotel Cortez

Santa Cruz

R2 136

per night

R2 136 total

A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

A spacious lobby with a curved reception desk, multiple seating areas, and a bar.

A table set for a meal with a view of a body of water and decorative lighting.

A spacious indoor area with multiple dining tables and chairs, a staircase, and large windows offering a view of the outdoors.

Sun Hotel

Santa Cruz

R207 off

R1 867

per night

R1 867 total

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

A modern outdoor pool area with a red brick wall, a large mural, and outdoor furniture.

A long bar with a wooden countertop, shelves with glassware, and framed pictures on the wall.

An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

R1 072 off

R1 720

per night

R1 720 total

A modern rooftop pool with a city view, wooden flooring, and a seating area.

A modern kitchen with a built-in grill, a black countertop, and a wall mural of tropical leaves.

A modern hotel room with a bed, bedside table, and a desk with a chair.

A modern office space with a dark wood desk, a black office chair, a flat-screen TV mounted on the wall, and an air conditioning unit.

AMERICA APARTMENTS

Santa Cruz

R61 off

R546

per night

R546 total

A modern bedroom with a bed, bedside table, and a desk with a laptop.

A modern kitchen with a wooden countertop, various appliances, and a dining area with chairs and a table.

A modern bathroom with a glass shower, a potted plant, and a towel rack.

A modern bathroom with a glass shower enclosure, a potted plant, a towel rack, and a black countertop.

Hotel G

Santa Cruz

R168 off

R393

per night

R393 total

A modern hotel room with a large bed, bedside tables, a desk with a chair, a small fridge, and a TV mounted on the wall.

A hotel room with two beds, a sofa, a TV, and a wall-mounted light fixture.

A paved outdoor area with a row of chairs, a planter with large-leafed plants, and a staircase leading to a higher level.

HOTEL OSHO

Santa Cruz

R115 off

R1 034

per night

R1 034 total

A spacious lobby with a high ceiling, modern furniture, and a large chandelier.

A spacious, well-lit interior with a modern white sofa set, a glass coffee table, and a dining area with red tablecloths.

A modern interior with a white sofa, a dining area, and a staircase.

A rooftop bar with a pool, lounge chairs, and a city view.

Hotel Arenal

Santa Cruz

R167 off

R948

per night

R948 total

A hotel room with a large window, a desk with a chair, a bed with white bedding and a blue accent, and a TV mounted on the wall.

A hotel entrance with glass doors, a sign reading "LP HOTELES", and a green wall.

A modern restaurant interior with high tables and chairs, a large window with a view of the city, and a mural of a pink cherry blossom tree.

A modern lobby with a glass wall, a blue sofa, a glass table, and a patterned ottoman.

Hotel LP Santa Cruz Centro

Santa Cruz

R292 off

R650

per night

R730 total

A buffet setup with various food items and beverages.

A hotel reception area with a modern design, featuring a reception desk, seating area, and a wall with various artworks.

A corridor with wooden doors, orange walls, and a carpeted floor.

A modern hotel room with a large bed, a desk, a chair, and a view of the outside.

Hotel LP Equipetrol

Santa Cruz

R437 off

R1 019

per night

R1 099 total

A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

A buffet setup with various food items and a serving area.

A hotel room with two beds, a desk, a television, and a small kitchenette.

A hotel with a unique wavy facade, multiple parking spaces, and a clear blue sky.

Hotel Las Américas

Santa Cruz

R46 off

R417

per night

R417 total

Check out pet-friendly hotels in Santa Cruz

A modern lobby with seating areas, a coffee table, and a large potted plant.

A modern dining area with green chairs, a long table, and a wall with geometric patterns.

A modern hotel with multiple floors, large windows, and a prominent red sign on the facade.

A hotel interior with a modern design, featuring a large window with a view of palm trees and a sign that reads "ibis HOTEL". There are three green chairs and a small round table.

Ibis Santa Cruz DE LA Sierra

Santa Cruz

R696

R696 total

11 Sept - 12 Sept

A buffet setup with various food items and beverages.

A hotel reception area with a modern design, featuring a reception desk, seating area, and a wall with various artworks.

A corridor with wooden doors, orange walls, and a carpeted floor.

A modern hotel room with a large bed, a desk, a chair, and a view of the outside.

Hotel LP Equipetrol

Santa Cruz

R577

R657 total

06 Sept - 07 Sept

A modern rooftop pool with a city view, wooden flooring, and a seating area.

A modern kitchen with a built-in grill, a black countertop, and a wall mural of tropical leaves.

A modern hotel room with a bed, bedside table, and a desk with a chair.

A modern office space with a dark wood desk, a black office chair, a flat-screen TV mounted on the wall, and an air conditioning unit.

AMERICA APARTMENTS

Santa Cruz

R546

R546 total

03 Oct - 04 Oct

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

A multi-level indoor space with a pool, wooden flooring, and potted plants.

A rooftop pool area with a glass balustrade, wooden deck, and a seating area with cushions and a small table.

A room with a bed, a small wooden stool, a potted plant in a black frame, and a door in the background.

Cosmopolitano Hotel Boutique

Santa Cruz

R878

R878 total

05 Oct - 06 Oct

A modern hotel room with a large bed, bedside tables, a desk with a chair, a small fridge, and a TV mounted on the wall.

A hotel room with two beds, a sofa, a TV, and a wall-mounted light fixture.

A paved outdoor area with a row of chairs, a planter with large-leafed plants, and a staircase leading to a higher level.

HOTEL OSHO

Santa Cruz

R872

R872 total

01 Oct - 02 Oct

A modern hotel room with a bed, a nightstand, a lamp, a painting, a kitchen area, and a bathroom.

A modern kitchen with wooden cabinets, a black countertop, and a built-in stove.

A compact kitchen with a stove, sink, and coffee maker. A bed with a blue pillow is visible in the background.

A cozy seating area with a round wooden table, a white cup, and a book.

Equipetrol Suites Apart Hotel

Santa Cruz

R820

R820 total

06 Sept - 07 Sept

Prince Hotel

Santa Cruz

R776

R807 total

06 Sept - 07 Sept

A modern bedroom with a bed, bedside table, and a desk with a laptop.

A modern kitchen with a wooden countertop, various appliances, and a dining area with chairs and a table.

A modern bathroom with a glass shower, a potted plant, and a towel rack.

A modern bathroom with a glass shower enclosure, a potted plant, a towel rack, and a black countertop.

Hotel G

Santa Cruz

R393

R393 total

05 Oct - 06 Oct

A hotel room with a large window, a desk with a chair, a bed with white bedding and a blue accent, and a TV mounted on the wall.

A hotel entrance with glass doors, a sign reading "LP HOTELES", and a green wall.

A modern restaurant interior with high tables and chairs, a large window with a view of the city, and a mural of a pink cherry blossom tree.

A modern lobby with a glass wall, a blue sofa, a glass table, and a patterned ottoman.

Hotel LP Santa Cruz Centro

Santa Cruz

R650

R730 total

23 Sept - 24 Sept

A room with a red sofa, a small black table, and a wooden door.

A grand staircase with ornate railings, marble flooring, and a seating area with purple armchairs.

A hotel room with two beds, a desk with a lamp, a chair, and a large window with curtains.

A hotel room with a bed, a desk, a chair, a table, a TV, and a mirror.

Gran Hotel Santa Cruz

Centro Histórico

R827

R935 total

07 Sept - 08 Sept

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Go beyond your typical stay in Santa Cruz

Pet friendly

Spa

Pool

Family friendly

Hot tub

Our prices for hotels in Santa Cruz are cheapest in February

Top neighbourhoods in Santa Cruz

Hamacas

Urubó

Zona Sur (South Zone)

Equipetrol

Centro Histórico

Top landmarks in Santa Cruz

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)

If you're planning a bit of sightseeing during your trip, head to Plaza 24 de Septiembre – just one of the monuments in central Santa Cruz.

An interior of a church with high arched ceilings, wooden pews, and a central altar.

San Lorenzo Cathedral

9.0/10 (84 reviews)

San Lorenzo Cathedral is in the heart of Santa Cruz, so why not stop by during your stay?

Ventura Mall

9.0/10 (183 reviews)

If you like shopping, take time out to go to Ventura Mall when in Santa Cruz.

Guembe Biocenter

8.8/10 (60 reviews)

Ready for an education in local botany? Guembe Biocenter should make your list of places to visit, located 1.2 mi (2 km) from central Colinas del Urubo. Want to stretch your legs a little more? Head to Arenal Park, located nearby.

Santa Cruz Zoo

8.4/10 (53 reviews)

It's feeding time at the zoo! If you want to be reminded of some of the great animals our world is home to, you might want to pay a visit to Santa Cruz Zoo, located 1.7 mi (2.8 km) from central Santa Cruz. If you have fun at Santa Cruz Zoo, you'll love Guembe Biocenter and Artecampo, both located nearby.

Cine Center

8.0/10 (53 reviews)

Cine Center is 1 mi (1.6 km) from central Santa Cruz, why not stop by during your stay? If you enjoy the show and want to see another, Casa Municipal de Cultura Raúl Otero Reiche isn't far.

Ramon Tahuichi Aguilera Stadium

8.4/10 (18 reviews)

You can catch an event at Ramon Tahuichi Aguilera Stadium, located 0.8 mi (1.3 km) from central Santa Cruz.

Las Brisas Shopping Center

8.4/10 (40 reviews)

If you like shopping, take time out to go to Las Brisas Shopping Center when in Santa Cruz.

Learn more about Santa Cruz

Santa Cruz is applauded for its cultural attractions such as Cine Center and Ethno-folkloric Museum.

See all hotels in Santa Cruz

A colonial-style building with a bell tower, palm trees, and a paved walkway.

Check out reviews of Santa Cruz hotels guests love

Hotel Cortez

Hotel Cortez

10/10 Excellent

"Great space"

Sun Hotel

Sun Hotel

10/10 Excellent

"The staff was wonderful,airport shuttle was on time, the room was very clean!!"

Hotel Las Américas

Hotel Las Américas

10/10 Excellent

"DELICIOSO EL DESAYUNO"

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent

"Breakfast is wonderful"

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

10/10 Excellent

"La ubicación es muy buena y puedes caminar por la zona"

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

10/10 Excellent

"All around good price and location"

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

10/10 Excellent

"Staff was super as well as how clean the room was."

HOTEL OSHO

HOTEL OSHO

10/10 Excellent

"Good"

Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

10/10 Excellent

"Todo muy bien"

Frequently asked questions

Can I book a refundable accommodation option in Santa Cruz?

If you want the flexibility to change your plans to Santa Cruz, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Santa Cruz if I want a holiday rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 23 holiday homes. In addition, you can choose from 199 apartments.

What will the weather in Santa Cruz be like during my visit?

Santa Cruz is a great place to visit to enjoy the sunshine at any time of year, with an average temp of 21°C.

Why should I book my Santa Cruz hotel with Hotels.com?

There are lots of reasons to book your Santa Cruz trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

Find out more about Santa Cruz

Santa Cruz: A Vibrant Tapestry of Nature's Blooms and Architectural Wonders

Nestled in the heart of Bolivia, Santa Cruz captivates with its vibrant cityscape, lush floral displays, and the majestic Cathedral that graces its skyline. Embracing Bolivian hospitality, visitors can savour the charm of central Santa Cruz and its rich cultural heritage, making it a perfect destination for a memorable next stay. Experience the blend of modern life and traditional splendour in this dynamic city.

Discover great hotels near Santa Cruz

Santa Cruz, Santa Cruz, Bolivia offers a range of hotels from cosy, comfortable stays to luxurious options, often rated up to five stars. Ideal accommodations come with modern amenities, welcoming lounges and elegant dining areas, ensuring a pleasant stay for travellers. Here are some of the most popular hotels with our travelers near Santa Cruz:

Hotel Rio Selva Resort Santa CruzOpens in a new window: This 3.0-star hotel offers travellers a comfortable and inviting experience, highlighted by its thoughtfully curated amenities for children including a free crib, shared playground, supervised childcare on site, a child-friendly pool, and on-site babysitting childcare. Ideal for leisure travellers seeking a relaxed and family-friendly retreat, the property provides a welcoming atmosphere and smooth service throughout your stay.
Novotel Santa Cruz De La SierraOpens in a new window: This 5.0-star hotel boasts an impressive guest rating and a luxurious setting tailored for leisure travellers. Guests can indulge in high-end experiences with standout features such as a rooftop bar, spa, infinity pool, express check-in, and curated high-quality amenities. The property offers an atmosphere of elegant design and premium comfort, ensuring a distinctive and memorable journey.
Marriott Santa Cruz de la Sierra HotelOpens in a new window: This 5.0-star hotel, with an outstanding guest rating, dazzles leisure travellers with its luxurious and boutique ambiance. Highlighting a range of curated experiences, guests can enjoy high-end offerings such as an infinity pool, rooftop bar, spa, high-end restaurant, and express check-in. The property exudes a refined architectural design and a smooth service, promising a journey filled with premium comfort and top-tier amenities.

4 tips for savvy savings when booking a hotel in Santa Cruz

Book for the cheapest times: The most affordable time to visit Santa Cruz is from June to August, when hotel prices are lower. For an enriching experience, it's recommended to stay for at least 3 to 4 days to thoroughly enjoy the city's key landmarks and cultural sites. During your visit, you can explore charming cafes, indulge in shopping, admire the local flora, visit the zoo, and partake in excursions centred around the area's history. Additionally, there are opportunities for birdwatching and enjoying local soccer matches, all of which provide great value for money while travelling on a budget. As a bonus, prices may drop during this period, making it an even more budget-friendly option for your getaway.
Look for last-minute deals on Hotels.com: To discover last-minute deals to Santa Cruz, visit the DealsOpens in a new window or Last-Minute Deals section on Hotels.com, where you may find discounted hotel options as your travel date approaches. You could also enable email alerts or push notifications from Hotels.com to stay updated on flash sales and exclusive promotions, helping you seize any opportunities to save. Additionally, Smart Shopping is a useful tool within the app that allows you to compare hotel prices and amenities, ensuring you’re informed if prices drop or rooms become available, making your last-minute getaway even more accessible.
Be flexible with dates: Prices may vary depending on factors such as the hotel's location, star rating, and time of year, so remaining flexible with your dates could help you save on your stay in a Santa Cruz hotel. For those seeking unique experiences, boutique hotels may offer a more personalised experience and occasionally better value. When you book with Hotels.com, we will inform you if the price for your selected dates is above or below the average, and if it appears to be on the higher side, we might suggest more affordable dates to help you find a better deal.
Consider your location: Hotels situated near the city centre generally tend to be more expensive, but with Santa Cruz's excellent public transport connections, you may discover a more affordable independent hotel further afield that remains well-connected. For those keen to explore alternative, less crowded neighbourhoods or even lesser-known nearby towns, there is often great value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Santa Cruz

Santa Cruz experiences its lowest average temperature in June, at 67.8°F (19.9°C), while October is the hottest month, with an average temperature of 79.5°F (26.4°C). January is typically the wettest month. If you’re looking to soak up the lively atmosphere in Santa Cruz, January, July, and September are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is sunny to mostly sunny, with little to no rainfall. However, if you prefer a more relaxed experience, May, October, and December are perfect for a quieter getaway, marked by light rainfall and mostly sunny conditions.

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